Welcome to the ACTA2 Alliance Foundation. We invite you to be part of a historic medical breakthrough for Multisystemic Smooth Muscle Dysfunction Syndrome (MSMDS), an ultra-rare genetic disease affecting only 70 patients worldwide, mostly children.

Understanding MSMDS

MSMDS is a genetic disease with severe vascular implications that puts patients at risk of strokes and aortic dissections from infancy. MSMDS also leads to life-challenging complications in other parts of the body where smooth muscle cells are present.

For families of MSMDS patients, every day is filled with uncertainty, as there are currently no treatments available to stop this devastating disease.

The Hope of research

Right now, researchers are working tirelessly to develop new therapies that could change the future for MSMDS patients. These efforts include innovative gene therapies and cutting-edge treatments to stop the disease's progression.

With more funding, we can accelerate this vital work and bring these life-changing treatments from the lab to the families who need them. Not only improving MSMDS patients’ lives but also paving the way for future medical breakthroughs.

Make an Impact Today

You have the chance today to join us in this vital mission and, with your donation, help us fund critical research and development efforts. Your support could lead to treatments that prevent strokes, stabilize life-threatening vascular complications, and give MSMDS patients like our children a brighter future.


Together, we can turn today’s hope into tomorrow’s reality.

Thank you for your generosity and support. Together, we are making history.

The ACTA2 Alliance Foundation and the MSMDS community deeply appreciate your commitment to this cause.

For more information, please contact us at msmds@acta2alliance.org.

Your contribution can change lives. Thank you for being a part of this  life-changing journey.